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Post-doc in Molecular Neurobiology (Donders Institute, Radboud University, Nijmegen)
To jobs overview| Application Deadline | 01-03-2010 |
|---|---|
| Where | Nijmegen, The Netherlands |
| INST / ORG | Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands |
| Contact Name | Prof. Dr. Gerard Martens |
| Contact Email | E-Address |
| Contact Phone | +31-(0)24-3610564 |
A fundamental question in the neurobiology of psychiatric disorders is how the interaction between predisposing genes and a change in environment (e.g. early-life stressors) can produce a phenotype that is vulnerable to a neurodevelopmental disorder, such as schizophrenia. Central question of the project: what programs the brain for vulnerability to neurodevelopmental psychiatric disorders?
Backgound and research
environment
The challenge of our research is to map the brain from genotype to
molecular pathways in neurodevelopmental trajectories to neuronal
circuitry phenotypes and beyond to behaviour and cognition. Main focus
is on understanding the molecular basis of neurodevelopmental
psychiatric disorders. For this purpose, we use the phenotypically
well-characterized so-called APO-SUS and APO-UNSUS rats; the APO-SUS
rats display a complex phenotype also observed in patients with
schizophrenia. Goal is to establish the molecular-genetic and
neurobiological basis of the rat model. In translational research,
variations in human genes encoding pathways identified in the rat model
will be explored to identify susceptibility genes for psychiatric
disorders.
The research is performed within the Department of Molecular Animal
Physiology. The department is
housed in the Nijmegen Centre for Molecular Life Sciences (NCMLS) and is part of the Donders Centre for Neuroscience
within the Donders Institute for Brain, Cognition and Behaviour. The
NCMLS provides an excellent and challenging research environment.
Job description
You will work in the field of Molecular Neurobiology (including
neurodevelopmental aspects) and use in particular (epi)genetic,
molecular, cell-biological, physiological and behavioural research
approaches. You will explore the effects of the interaction between
(epi)genetic / molecular and environmental (early-life stress) factors
on brain development / behavioural phenotypes. The research will be
performed within the context of a TI Pharma project, with Lundbeck A/S
(Denmark) as industrial partner.
Requirements
- PhD degree in Molecular/Cellular Neurobiology, Molecular Life Sciences or equivalent
- relevant experience in Developmental Biology and/or with animal behavioural research is an advantage
- high affinity for fundamental research related to clinical problems
Terms of Employment
Initially one year and when successful two and then three years;
maximum salary: 3.678 euros per month.
Application and inquiries
Application should include a cover letter with motivation, a research
statement, a curriculum vitae, a list of publications and the names of
at least two independent referees. Send your application to: Prof. dr
Gerard Martens, Dept Molecular Animal Physiology, NCMLS, RT282, Radboud
University, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, The
Netherlands. Inquiries: Prof. dr Gerard Martens; tel:
+31-(0)24-3610564; e-mail: g.martens@ncmls.ru.nl.
keywords: Animal models, Biology, Neuroscience, Physiology, Psychiatry, Animal models
